C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/16 (2006.01) A61P 17/02 (2006.01) A61P 27/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/705 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2400040
The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.
La présente invention concerne des méthodes et des compositions permettant d'inhiber l'activité biologique des intégrines, la migration des cellules endothéliales et l'angiogénèse. L'invention concerne plus particulièrement des compositions contenant des domaines désintégrine ADAM ainsi que des procédés d'utilisation de ces compositions. Dans des modes de réalisation préférés, on utilise les méthodes et les compositions de l'invention afin d'inhiber l'angiogénèse et de traiter les maladies ou les états pathologiques induits par l'angiogenèse.
Black Roy Alvin
Cerretti Douglas Pat
Fanslow William C. III
Poindexter Kurt Matthew
Immunex Corporation
Smart & Biggar
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