Integrin antagonists

Details Integrin antagonists Integrin antagonists

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01) A61K 31/405 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) C07C 63/00 (2006.01) C07C 307/06 (2006.01) C07C 307/08 (2006.01) C07C 307/10 (2006.01) C07D 209/40 (2006.01) C07D 213/89 (2006.01) C07D 217/08 (2006.01) C07D 233/44 (2006.01) C07D 233/88 (2006.01) C07D 239/08 (2006.01) C07D 239/14 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2268916

This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are .alpha.v.beta.3 antagonists, .alpha.v.beta.5 antagonists or dual .alpha.v.beta.3/.alpha.v.beta.5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.

Cette invention a trait à certains nouveaux composés ainsi qu'à leurs dérivés, leur synthèse et leur utilisation en tant qu'antagonistes du récepteur de la vitronectine. Les composés, selon l'invention, antagonistes du récepteur de la vitronectine sont des antagonistes de alpha v beta 3, de alpha v beta 5 ou des antagonistes doubles de alpha v beta 3/ alpha v beta 5 qui se révèlent efficaces s'agissant d'inhiber la résorption osseuse, de traiter et de prévenir l'ostéoporose ainsi que d'inhiber la resténose, la rétinopathie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, l'inflammation et la croissance tumorale.

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