Integrin receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 45/06 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2386030

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3 and/or .alpha.v.beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.

La présente invention concerne des composés et des dérivés de ceux-ci, leur synthèse, et leur utilisation comme antagonistes des récepteurs de vitronectine. Les composés de cette invention sont plus particulièrement des antagonistes des récepteurs d'intégrine .alpha.v.beta.3 et/ou .alpha.v.beta.5 et ils sont utiles pour inhiber la résorption osseuse, pour traiter et prévenir l'ostéoporose, et inhiber la résténose vasculaire, la rétinopathie diabétique, la dégénération maculaire, angiogenèse, athérosclérose, l'arthrite inflammatoire, le cancer et la croissance de tumeurs à métastases.

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