Integrin receptor antagonists

Details Integrin receptor antagonists Integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 45/06 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2376077

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha..beta.3 and/or .alpha.v.beta.5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

L'invention concerne des composés ainsi que leurs dérivés, leurs synthèse et leur utilisation en tant qu'antagonistes des récepteurs de l'intégrine. D'une manière spécifique, lesdits composés sont des antagonistes des récepteurs de l'intégrine .alpha.v.beta.3 et/ou .alpha.v.beta.5 et permettent d'inhiber la résorption osseuse, de traiter et de prévenir l'ostéoporose, et d'inhiber la resténose vasculaire, la rétinophatie diabétique, la dégénérescence maculaire, l'angiogenèse, l'athérosclérose, les inflammations, les arthrites inflammatoires, les maladies virales, le cancer et la croissance des métastases tumorales.

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