Integrin targeted imaging agents

Details Integrin targeted imaging agents Integrin targeted imaging agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 47/48 (2006.01) C07D 215/233 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2474386

Emulsions preferably of nanopartides formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for QvP3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.

Cette invention a trait à des émulsions, composées, de préférence de nanoparticules formées à partir de substances perfluorées liquides à ébullition élevée. Ces particules, qui sont enrobées d'un enduit à base de lipide/tensioactif, sont rendues spécifiques de régions de cellules endothéliales par couplage à un ligand spécifique de l'intégrine QvP3, autre qu'un anticorps. Ces nanoparticules peuvent, en outre, contenir des agents actifs du point de vue biologique, des nucléides radioactifs ou d'autres agents d'imagerie.

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