Integrin targeting liposome for nucleic acid delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61K 51/12 (2006.01) C12N 15/63 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2449054

.alpha.v.beta.3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic .alpha.v.beta.3 integrin antagonist.

La présente invention concerne des liposomes ciblant le récepteur intégrine .alpha.¿v?.beta.¿3?, qui comprennent un amphiphile cationique tel qu'un lipide cationique, un lipide neutre et un lipide de ciblage. Le lipide de ciblage comprend un antagoniste non peptidique de l'intégrine .alpha.¿v?.beta.¿3?.

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