Intensely sweet l-aspartyl-3-(bicycloalkyl)-l-alanine alkyl...

C - Chemistry – Metallurgy – 07 – K

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530/5.06, 99/140

C07K 5/06 (2006.01) A23L 1/236 (2006.01) C07K 5/072 (2006.01)

Patent

CA 1321675

INTENSELY SWEET L-ASPARTYL-3-(BICYCLOALKYL)-L-ALANINE ALKYL ESTERS ABSTRACT OF THE DISCLOSURE The present invention relates to L-aspartyl-3- (bicycloalkyl)-L-alanine alkyl esters having high sweetness intensity, of the formula: Image wherein R1 is a substituted or an unsubstituted bicycloalkyl ring, said ring having 7 to 8 carbon atoms, the 2-position ring carbon atom is bound to the alanine moiety, the two carbon atoms of the ring that are vicinal to the 2-position carbon are each substituted by a hydrogen or lower alkyl, the total number of alkyl groups bound to the vicinal carbons is less than three, and R2 is methyl. The "2R" configuration enantiomers of the R1 group are especially preferred. In preferred embodiments of the invention, R1 is a bornyl, camphanyl, norbornyl, 1-methylnorbornyl, 3-methylnorbornyl, 7,7-dimethylnorbornyl, bicyclo [2.2.2] octyl, or pinanyl ring. The compounds of the invention, or edible salts thereof, can be used for sweetening edible products such as foods and beverages.

562455

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