Interacting site for gp41 on gp120 of hiv-1

Details Interacting site for gp41 on gp120 of hiv-1 Interacting site for gp41 on gp120 of hiv-1

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) C07H 21/04 (2006.01) C07K 14/155 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2483870

Mutations in the amino and carboxy terminal halves of HIV-1 gp120 and the carboxy terminus of gp41 are disclosed which contribute to the neutralization resistance and high infectivity phenotypes of HIV-1.

La présente invention concerne des mutations dans les moitiés amino et carboxy-terminales de la gp120 du VIH-1 et dans la terminaison de la gp41, qui contribuent aux phénotypes résistants à la neutralisation et à pouvoir infectieux élevé du VIH-1.

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