Interaction inhibitors of tcf-4 with beta-catenin

Details Interaction inhibitors of tcf-4 with beta-catenin Interaction inhibitors of tcf-4 with beta-catenin

C - Chemistry, Metallurgy

07

D

C07D 307/52 (2006.01) A61K 31/00 (2006.01) A61K 31/341 (2006.01) A61K 31/366 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/4196 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) A61K 31/433 (2006.01) A61K 31/4433 (2006.01) A61K 31/4709 (2006.01) A61K 31/473 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 249/00 (2006.01) C07D 261/08 (2006.01) C07D 261/14 (2006.01) C07D

Patent

CA 2453175

A compound of formula (I) is provided which is able to interact with .beta.- catenin/TCF-4 binding site, having a structure essentially equivalent to a pharmacophore (IA), as herein described.

L'invention se rapporte à un composé représenté par la formule (I), capable d'interagir avec le site de liaison de la .beta.-caténine/TCF-4, et présentant une structure essentiellement identique à celle d'un pharmacophore.

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