C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12N 15/57 (2006.01) C12P 19/00 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2332625
The present invention discloses an interaction between .beta.-APP and HsLON and the formation of a .beta.-APP:HsLON complex, or of the derivatives, fragments, analogs and homologs thereof, that were identified using a modified, improved yeast two hybrid assay system. Methodologies of screening these aforementioned complexes for efficacy in treating and/or preventing various diseases and disorders, particularly neurodegenerative disease, cardiomyopathy, diabetes, hearing loss, male infertility, mitochondrial DNA mutation associated disorders and the like, are also disclosed herein.
L'invention concerne une interaction de .beta.-APP et de HsLON et la formation d'un complexe .beta.-APP:HsLON ou de dérivés, de fragments, d'analogues et d'homologues correspondants, que l'on a identifié en utilisant un système d'essai modifié et amélioré à la levure avec double hybride. L'invention concerne en outre des procédés relatifs au dosage des types de complexe susmentionnés qui permettent de traiter et/ou de prévenir efficacement un certain nombre de maladies et de troubles, en particulier les affections neurodégénératives, la cardiomyopathie, le diabète, la surdité, la stérilité masculine, les troubles associés à la mutation d'ADN mitochondrial et autres.
Nandabalan Krishnan
Schulz Vincent Peter
Yang Meijia
Curagen Corporation
Ridout & Maybee Llp
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