Interaction of moraxella catarrhalis with epithelial cells,...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61P 31/04 (2006.01) C07K 14/195 (2006.01) C07K 14/22 (2006.01) C07K 19/00 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2618554

The present invention relates to extracellular matrix proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cellassociated fibronectin and laminin, and also to their ability to inhibit the complement system. These extracellular proteins are useful in the preparation of vaccines. The present invention provides peptides interacting with the fibronectin, laminin and complement system.

La présente convention concerne des protéines matricielles extracellulaires de moraxella catarrhalis et la capacité d'interagir avec des cellules épithéliales via une fibronectine et une laminine associée à la cellule et, également leur capacité d'inhiber le système complémentaire. Ces protéines extracellulaire conviennent pour la préparation de vaccins. Cette invention concerne des peptides interagissant avec la fibronectine, la laminine et le système complémentaire.

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