C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/42 (2006.01) A61P 25/00 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2398250
The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and a protein tyrosine phosphatase (PTP), e.g., PTPL1. The present invention provides methods for screening a PTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal NMDA- R signaling. The present invention further provides methods for isolating PTPL1 from a biological preparation.
L'invention concerne l'identification d'une liaison entre des sous-unités du récepteur de N-méthyl-D-aspartate (NMDA-R) et la tyrosine phosphatase (PTP), par exemple PTPL1. L'invention concerne également des méthodes permettant de cribler un agoniste ou un antagoniste de PTP qui module une signalisation de NMDA-R. L'invention concerne, en outre, des méthodes et des compositions permettant de traiter des troubles induits par une signalisation anormale de NMDA-R. L'invention concerne enfin des méthodes permettant d'isoler PTPL1 d'une préparation biologique.
Kask Kalev
Melcher Thorsten
Agy Therapeutics Inc.
Fetherstonhaugh & Co.
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