C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/42 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2548495
The present invention relates to the identification of STEP being as involved in signaling pathways relating to psychotic diseases, including schizophrenia, and other disorders in which NMDA receptor dysfunction is implicated. The present invention provides methods for screening STEP inhibitors that modulate NMDA-R signaling. The present invention also provides methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling.
L'invention concerne l'identification de STEP participant dans les voies de signalisation se rapportant à des maladies psychotiques, y compris la schizophrénie, et d'autres troubles liés au dysfonctionnement du récepteur NMDA. L'invention concerne des procédés permettant de cribler des inhibiteurs de STEP qui modulent la signalisation du NMDA-R. Elle concerne également des procédés et des compositions destinés au traitement des troubles médiés par une signalisation du NMDA-R anormale.
Braithwaite Steven
Jerecic Jasna
Urfer Roman
Pfizer Inc.
Smart & Biggar
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