C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) C07K 14/395 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2281983
The invention relates to the finding that the yeast protein Skn7 acts as a transcription factor and is involved in direct binding to DNA. Transcription by Skn7 involves cooperation with other cellular factors, including the proteins Yap1, Hsf1 and Mbp1. The binding of Skn7 to specific DNA sequences, and its interaction with other factors, provides targets for assays for screening putative inhibitors of fungal growth.
L'invention se rapporte à la découverte selon laquelle la protéine de levure Skn7 agit comme facteur de transcription et est impliquée dans la fixation directe sur l'ADN. La transcription par Skn7 comprend la coopération avec d'autres facteurs cellulaires, notamment les protéines Yap1, Hsf1 et Mbp1. La fixation de Skn7 sur des séquences spécifiques d'ADN et son interaction avec d'autres facteurs fournissent des cibles aux dosages qui permettent de cribler les inhibiteurs potentiels de la prolifération fongique.
Johnston Leland Herries
Morgan Brian Alexander
Raitt Desmond Colum
Kirby Eades Gale Baker
Medical Research Council
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