A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/557 (2006.01) A61K 9/127 (2006.01)
Patent
CA 2175350
This invention provides an interdigitation-fusion liposome comprising an arachidonic acid metabolite, a lipid bilayer comprising a lipid and an aqueous compartment comprising a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g., cell activation/adhesion disorders and inflammatory disorders.
L'invention porte sur un liposome d'interdigitation-fusion comprenant un métabolite d'acide arachidonique et une double couche de lipide faite d'un lipide et d'un compartiment aqueux à tampon de libération/inhibition. Les métabolites d'acide arachidonique préconisés sont des prostaglandines, spécialement du type PGE¿1?. Ces préparations à base de liposomes peuvent servir à traiter les animaux et l'homme atteints d'affections, de troubles ou de pathologies sensibles aux prostaglandines tels que p. ex. les troubles d'activation/adhérence cellulaire ou inflammatoires.
Janoff Andrew S.
Minchey Sharma R.
Osler Hoskin & Harcourt Llp
The Liposome Company Inc.
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