Interface medium for tissue surface probe

Details Interface medium for tissue surface probe Interface medium for tissue surface probe

G - Physics

02

B

G02B 21/33 (2006.01) A61B 5/00 (2006.01) G01N 21/01 (2006.01)

Patent

CA 2389450

A composition useful as an interface medium to optically couple and facilitate contact between a probe and a tissue surface, such as skin, is described. Compositions of the present invention have an index of refraction of approximately 1.4, which approximates the indices of both the skin and the probe, and may be clear in the spectral region of 270-500 nm, pH buffered, slippery, water soluble and viscous. The compositions may also be used to calibrate the application of pressure between a probe and a surface and standardize operation of the instrument, or adjust the surface to optimize use of the instrument.

La présente invention concerne une composition pouvant servir de milieu d'interface pour permettre un couplage optique et faciliter le contact entre un échantillon et une surface tissulaire, telle que la peau. Les compositions de la présente invention présentent un indice de réfraction d'environ 1,4, ce qui se rapproche des indices des deux éléments que sont la peau et l'échantillon, et peuvent être claires dans le domaine spectral de 270-500 nm, tamponnées à un pH, glissantes, solubles dans l'eau, et visqueuses. Les compositions peuvent également être utilisées pour calibrer l'application de pression entre un échantillon et une surface et standardiser le fonctionnement de l'instrument, ou pour adapter la surface dans le but d'optimiser l'utilisation de l'instrument.

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