Interfacial condensation of bioactive compounds and the...

Details Interfacial condensation of bioactive compounds and the... Interfacial condensation of bioactive compounds and the...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2067210

2067210 9105806 PCTABS00005 This invention provides a method of preparing conjugates of bioactive compounds and site-specific compounds in which covalent bonding between the compounds is effected by interfacial condensation while protecting the active binding sites from the condensation reaction. This provides very high yields of the bioactive, site-specific conjugate, the products are homogeneous and it provides novel conjugate products. It is of particular advantage for monoclonal antibodies conjugated with cytotoxic agents.

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