G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A61K 38/45 (2006.01) A61K 45/08 (2006.01) C12N 5/00 (2006.01) C12N 15/54 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2384139
A method of identifying a secondary target site comprising: providing a plurality of cells having a genome, which includes at least one primary gene encoding telomerase activity and a promoter that can direct the over expression of said primary gene; effecting one or more mutations in genome of said cells, at one or more secondary sites; selecting those cells having at least one mutation that proves lethal to said cells when said primary gene is over expressed; and determining a site in the genome of said cells in which said at least one lethal mutation is located, to provide a secondary target site. And a pharmaceutical composition comprising an effective amount of a drug or drug candidate and a pharmaceutically acceptable carrier or diluent, said drug or drug candidate capable of interacting with, binding to, or inhibiting the expression or activity of a gene product associated with a secondary target site in the genome of a cell exhibiting aberrant telomerase activity, which site can accommodate at least one mutation that can rove lethal to said cell.
L'invention concerne de nouvelles séquences nucléotidiques, ainsi que les séquences polypeptidiques dérivées de celles-ci, impliquées dans la régulation des télomères de mammifères et des télomères de levure. L'invention concerne également des procédés de criblage de médicaments et des compositions. L'invention concerne encore des méthodes impliquant l'utilisation diagnostique et/ou thérapeutique de ce(s) gène(s)/cette/ces protéine(s), de préférence dans le traitement du cancer et du vieillissement.
Bedalov Antonio
Friend Steve
Nelson Melissa Dashiel
Paddison Patrick
Fred Hutchinson Cancer Research Center
Robic
LandOfFree
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