Interferon alpha antibodies and their uses

Details Interferon alpha antibodies and their uses Interferon alpha antibodies and their uses

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2546054

The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.

Anticorps monoclonaux isolés anti-interféron alpha, en particulier anticorps monoclonaux humains, qui inhibent l'activité biologique de sous-types multiples d'interféron (IFN) alpha, mais qui n'inhibent pas sensiblement l'activité biologique de IFN alpha 21 ou l'activité biologique d'IFN bêta ou d'IFN oméga. Des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques contenant les anticorps selon la présente invention sont également décrits. La présente invention concerne encore des méthodes permettant d'inhiber l'activité biologique d'IFN alpha à l'aide des anticorps selon la présente invention, ainsi que des méthode de traitement de maladies ou de troubles pathologiques médiés par IFN alpha, tels que les maladies auto-immunes, le rejet de greffon et la réaction du greffon contre l'hôte, par administration des anticorps selon la présente invention.

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