Interferon alpha carrier prodrugs

A - Human Necessities – 61 – K

Patent

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A61K 47/48 (2006.01)

Patent

CA 2753001

The present invention relates to a pharmaceutical composition comprising a water-soluble polymeric carrier linked prodrug of interferon alpha, wherein the prodrug is capable of releasing free interferon alpha, wherein the release half life under physiological conditions is at least 4 days. The invention further relates to prodrugs for said pharmaceutical composition and their use for treating, controlling, delaying or preventing a condition that can benefit from interferon alpha treatment, such as hepatitis C.

La présente invention concerne une composition pharmaceutique comprenant un promédicament d'interféron alpha lié à un vecteur soluble dans l'eau, le promédicament étant capable de libérer l'interféron alpha libre, la demi-vie de libération dans des conditions physiologiques étant d'au moins 4 jours. L'invention concerne en outre des promédicaments de ladite composition pharmaceutique et leur utilisation pour traiter, surveiller, retarder l'apparition ou prévenir une condition qui peut bénéficier d'un traitement par l'interféron alpha, telle que l'hépatite C.

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