Interferon-alpha induced gene

Details Interferon-alpha induced gene Interferon-alpha induced gene

C - Chemistry, Metallurgy

12

N

C12N 15/20 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61P 31/00 (2006.01) C07K 14/47 (2006.01) C07K 14/56 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2421234

The present invention relates to identification of a gene upregulated by interferon-.alpha. administration corresponding to the cDNA sequences set forth in SEQ. ID. No. 1 or in SEQ. ID. No. 3. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-.alpha. and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

La présente invention se rapporte à l'identification d'un gène régulé positivement par l'administration d'interféron alpha et correspondant aux séquences d'ADNc présentés dans SEQ.ID.No 1 ou dans SEQ.ID.No 3. La détermination des produits d'expression de ce gène s'avère présenter une utilité pour la prédiction de la réceptivité à un traitement effectué par avec l'interféron alpha et d'autres interférons qui agissent au niveau du récepteur des interférons du type 1. L'invention se rapporte également à l'utilisation thérapeutique de la protéine codée par ce gène.

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