Interferon-alpha induced gene

Details Interferon-alpha induced gene Interferon-alpha induced gene

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2520253

The present invention relates to identification of a gene upregulated by interferon-.alpha. administration corresponding to the cDNA sequence set forth in SEQ. ID. No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-.alpha. and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

La présente invention a trait à l'identification d'un gène ayant subi une régulation positive par l'administration de l'interféron-.alpha. correspondant à la séquence formulée dans SEQ. ID. No. 1. La détermination de produits d'expression de ce gène est considérée comme présentant une utilité dans la prédiction de la sensibilité à un traitement avec l'interféron-.alpha. et d'autres interférons qui agissent au niveau du récepteur d'interférons de Type 1. L'invention a également trait à l'utilisation thérapeutique de la protéine codée par ce même gène.

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