Interferon-alpha induced gene

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2437898

The present invention relates to identification of a gene upregulated by interferon-.alpha. administration corresponding to the cDNA sequence set forth in SEQ. ID. No. 1 and SEQ. ID. No. 3. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-.alpha. and othe interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

La présente invention concerne l'identification d'un gène régulé positivement au moyen de l'administration d'interféron-.alpha.? correspondant à la séquence d'ADNc définie dans la SEQ.ID. No. 1 et No. 3. La détermination des produits d'expression de ce gène peut s'avérer utile dans la prédiction de la faculté de réponse au traitement avec l'interféron -.alpha. ; et avec d'autres interférons qui agissent au niveau du récepteur d'interféron de type 1. L'utilisation thérapeutique de la protéine codée par ce gène est également considérée.

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