Interferon-alpha induced gene

Details Interferon-alpha induced gene Interferon-alpha induced gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2430297

The present invention relates to identification of a gene upregulated by interferon-.alpha. administration corresponding to the cDNA sequence set forth in SEQ.ID. No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-.alpha. and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

La présente invention concerne l'identification d'un gène régulé positivement au moyen de l'administration d'interféron-.alpha. correspondant à la séquence d'ADNc définie dans la SEQ.ID. No. 1. La détermination des produits d'expression de ce gène peut s'avérer utile dans la prédiction de la faculté de réponse au traitement avec l'interféron-.alpha. et avec d'autres interférons qui agissent au niveau du récepteur d'interféron de type 1. L'utilisation thérapeutique de la protéine codée par ce gène est également considérée.

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