Interferon-alpha induced gene

Details Interferon-alpha induced gene Interferon-alpha induced gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2394303

The present invention relates to identification of a gene upregulated by interferon-.alpha. administration corresponding to the cDNA sequence set forth in SEQ.ID.No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon- .alpha. and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

L'invention concerne l'identification d'un gène régulé de manière positive par l'administration d'interféron-.alpha. correspondant à la séquence d'ADNc exposée dans la SEQ.ID.No. 1. La détermination de produits d'expression de ce gène est utile dans la prédiction de la sensibilité au traitement à base d'interféron-.alpha. et d'autres interférons, lesquels agissent au niveau du récepteur de l'interféron de type 1. L'invention concerne également l'utilisation thérapeutique de la protéine codée par ce même gène.

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