Interferon-.alpha. induced gene

Details Interferon-.alpha. induced gene Interferon-.alpha. induced gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2495289

The present invention relates to identification of a gene upregulated by interferon- administration corresponding to the cDNA sequence set forth in SEQ. 1D. No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon- and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

La présente invention se rapporte à l'identification d'un gène qui est régulé à la hausse par l'administration de l'interféron-.alpha., qui correspond à la séquence d'ADNc formulée dans SEQ. ID. N· 1. La détermination de produits d'expression de ce gène est jugée utile pour prédire la réceptivité au traitement faisant appel à l'interféron-.alpha. et à d'autres interférons qui agissent au niveau du récepteur de l'interféron de type 1. L'invention concerne également l'utilisation thérapeutique de la protéine codée par ledit gène.

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