C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2397254
The present disclosure relates to identification of genes upregulated by interferon-.alpha. administration, in particular the human genes corresponding to the cDNA sequences in GenBank designated g4586459, g2342476, g3327161 and g4529886. Determination of expression products of these genes is proposed as having utility in predicting responsiveness to treatment with interferon- .alpha. and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the proteins encoded by the same genes is also envisaged.
La présente invention concerne l'identification de gènes surrégulés par l'administration d'interféron .alpha., en particulier les gènes humains correspondant aux séquences de c-ADN de la banque de gènes désignés comme g4586459, g92342476, g3327161 et g4529886. La détermination des produits d'expression de ces gènes permet de prévoir la réponse au traitement avec l'interféron .alpha. et d'autres interférons agissant comme récepteurs de l'interféron de type 1. L'invention concerne également l'utilisation thérapeutique des protéines codées par les mêmes gènes.
Dron Michel
Meritet Jean Francois
Tovey Michael Gerard
Macrae & Co.
Pharma Pacific Pty Ltd.
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