G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2397369
The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-.alpha. administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression products of these genes is proposed as having utility in predicting responsiveness to treatment with interferon- .alpha. and other interferons which act at the Type 1 interferon receptor.
L'invention concerne l'identification de gènes connus comme étant des gènes régulés positivement par administration d'interféron-.alpha., en particulier les gènes humains correspondant à la séquence d'ADNc d'une génothèque appelée g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 et g4507170. La détermination des produits d'expression de ces gènes présente une utilité dans la prédiction de la sensibilité à un traitement à l'interféron-.alpha., et à d'autres interférons qui agissent au niveau du récepteur d'interféron de type 1.
Dron Michel
Meritet Jean-Francois
Tovey Michael Gerard
Macrae & Co.
Pharma Pacific Pty Ltd.
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