C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/21 (2006.01) A61K 9/127 (2006.01) A61K 48/00 (2006.01) C07K 14/54 (2006.01) C07K 14/56 (2006.01) C12N 5/10 (2006.01) C12N 15/24 (2006.01) C12N 15/85 (2006.01) C12N 15/88 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2323604
The present invention relates to gene delivery and gene therapy, and provides novel nucleic acid constructs for expression of interferon alpha in a mammal, formulations for delivery that incorporate a nucleic acid construct for expression, and methods for preparing and using such constructs and formulations. In particular, this invention relates to plasmid constructs for delivery of therapeutic interferon alpha encoding nucleic acids to cells in order to modulate tumor activity, methods of using those constructs (including combination therapy with other agents, such as cytokines, preferably IL-12), as well as methods for preparing such constructs.
L'invention concerne une administration et une thérapie géniques, de nouvelles constructions d'acide nucléique permettant d'exprimer l'interféron alpha chez un mammifère, des formulations en vue d'une administration, qui incorporent une construction d'acide nucléique en vue d'une expression, et des procédés de préparation et d'utilisation de ces constructions et de ces formulations. L'invention concerne, en particulier, des constructions de plasmide permettant d'administrer à des cellules un interféron thérapeutique alpha, codant pour des acides nucléiques de façon à moduler une activité tumorale, des procédés d'utilisation de ces constructions (comprenant une thérapie de combinaison avec d'autres agents tels que les cytokines, de préférence IL-12), ainsi que des procédés de préparation de ces constructions.
Nordstrom Jeff
Pericle Federica
Ralston Robert
Rolland Alain
Smart & Biggar
Valentis Inc.
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