Interferon alpha receptor 1 antibodies and their uses

Details Interferon alpha receptor 1 antibodies and their uses Interferon alpha receptor 1 antibodies and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2570823

The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.

La présente invention concerne des anticorps monoclonaux humains isolés, se liant au récepteur IFNAR-1 et capables d'inhiber l'activité biologique d'interférons de type I. L'invention concerne également des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant lesdits anticorps. Cette invention se rapporte en outre à des procédés pour inhiber des troubles médiés par des interférons de type I au moyen des anticorps de l'invention, y compris des procédés pour traiter les maladies autoimmunes, le rejet de greffon ou la maladie du greffon contre l'hôte au moyen desdits anticorps.

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