Interferon-beta fusion proteins and uses

Details Interferon-beta fusion proteins and uses Interferon-beta fusion proteins and uses

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/565 (2006.01) C07K 19/00 (2006.01) C12N 15/22 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2343094

A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.

L'invention concerne un polypeptide de fusion possédant la séquence d'acides aminés X-Y-Z, ou une partie de cette séquence. X est la séquence d'acides aminés d'un interféron bêta glycosylé. Y est une fraction de liaison facultative. Z est un polypeptide renfermant au moins une partie d'un polypeptide autre que l'interféron bêta glycosylé. De préférence, X est un interféron bêta 1a humain. L'invention concerne également des mutants de l'interféron bêta 1a.

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