Interferon beta-like molecules for treatment of stroke

Details Interferon beta-like molecules for treatment of stroke Interferon beta-like molecules for treatment of stroke

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2477577

The present invention relates to use of interferon beta-like polypeptides for treatment of stroke or transient ischemic attach in a primate, preferably in a human. More particularly, the interferon beta-like polypeptides differs from the amino acid sequence of wild-type human IFNB (SEQ ID NO:2) in that at least one glycosylation site, preferably at least one in vivo N-glycosyltaion site has been introduced. Optionally the interferon beta-like polypeptides are PEGylated.

L'invention concerne l'utilisation de polypeptides de type interféron-bêta pour le traitement d'accidents vasculaires cérébraux ou d'accidents ischémiques transitoires chez les primates, de préférence chez l'être humain. Plus particulièrement, lesdits polypeptides de type interféron-bêta diffèrent de la séquence d'acide aminés d'IFNB (SEQ ID NO:2) humain de type sauvage en ce que au moins un site de glycosylation, de préférence au moins un site de N-glycosylation in vivo a été introduit. Eventuellement, lesdits polypeptides de type interféron-bêta sont pégylés.

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