C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) C07K 14/00 (2006.01) C07K 14/57 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2297692
The present invention concerns molecules which bind and neutralize the cytokine interferon-gamma. More specifically, the present invention relates to sheep-derived antibodies and engineered antibody constructs, such as humanized single-chain Fv fragments, chimeric antibodies, diabodies, triabodies, tetravalent antibodies, peptabodies and hexabodies which can be used to treat diseases wherein interferon-gamma activity is pathogenic. Examples of such diseases are: septic shock, cachexia, multiple sclerosis and psoriasis.
La présente invention concerne des molécules qui fixent et neutralisent la cytokine interféron-gamma. Plus particulièrement, cette invention traite d'anticorps issus du mouton et de produits de recombinaison anticorps manipulés, tels que des fragments Fv à chaîne unique humanisés, des anticorps chimères, des diacorps, des triacorps, des anticorps tétravalents, des peptacorps et des hexacorps qui peuvent être utilisés pour traiter des maladies pour lesquelles l'activité interféron-gamma est pathogène. Parmi ces maladies on trouve, le choc septique, la cachexie, la sclérose en plaques et le psoriasis.
Buyse Marie-Ange
Sablon Erwin
Innogenetics N.v.
Smart & Biggar
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