Interferon gamma conjugates

Details Interferon gamma conjugates Interferon gamma conjugates

C - Chemistry, Metallurgy

12

N

C12N 15/23 (2006.01) A61K 38/21 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07K 1/113 (2006.01) C07K 14/57 (2006.01) C07K 17/08 (2006.01) C07K 17/10 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2390292

A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one introduced and/or at least one removed amino acid residue comprising an attachment group for the non-polypeptide moiety. The conjugate may be used for treatment of various diseases.

Selon l'invention, un conjugué présente une activité d'interféron gamma et contient au moins une première fraction non polypeptidique liée par covalence à un polypeptide IFG dont la séquence d'acide aminé diffère de celle d'un polypeptide IFNG apparenté par au moins un résidu d'acide aminé introduit et/ou par au moins un résidu d'acide aminé enlevé comprenant un groupe se fixant à ladite première fraction non polypeptidique. Ce conjugué convient particulièrement pour le traitement de différentes maladies.

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