C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/23 (2006.01) A61K 38/21 (2006.01) A61P 11/00 (2006.01) C07K 14/57 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2443277
The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in particular for the treatment of interstitial pulmonary diseases, such as idiopathic pulmonary fibrosis. These novel polypeptide variants all comprise the substitution S99T as compared to the amino acid sequence of huIFNG or fragments thereof. By performing this mutation the naturally occurring N-glycosylation site present at position 97 is significantly beter utilized. Preferably, the variants comprise further modifications, e.g. in order to increase the AUC of such variatns when administered subcutaneously.
La présente invention concerne de nouvelles variantes polypeptidiques à interféron gamma ayant une activité d'interferon gamma (IFNG), leurs procédés de préparation, les compositions pharmaceutiques contenant ces variantes polypeptidiques et leur utilisation pour traiter des maladies, notamment des maladies pulmonaires interstitielles comme la fibrose pulmonaire idiopathique. Toutes ces nouvelles variantes polypeptidiques contiennent la substitution S99T comparé à la séquence d'acides aminés de huIFNG ou à des fragments de cette dernière. Cette mutation permet de nettement mieux utiliser le site de N-glycosylation apparaissant naturellement et étant présent à la position 97. Ces variantes contiennent naturellement d'autres modifications, notamment de l'ordre de l'augmentation de la surface sous la courbe de telles variantes en cas d'administration sous-cutanée.
Maxygen Holdings Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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