C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/20 (2006.01) A61K 31/70 (2006.01) A61K 38/21 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/555 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2247075
HKAFE42 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKAFE42 polypeptides and polynucleotides in the design of protocols for the treatment of disorders of the central nervous system (including anxiety, depression, schizophrenia and Parkinson's disease), muscle diseases (including muscular dystrophies and multiple sclerosis), Alzheimer's disease, hematopoetic disorders, allergic diseases, autoimmune diseases, immunodeficiency and cancer, among others, and diagnostic assays for such conditions.
Polypeptides et polynucléides HKAFE42 et méthodes de production de ces polypeptides par des techniques recombinantes. Sont également divulguées des méthodes pour l'utilisation des polypeptides et polynucléides HKAFE42 dans la conception de protocoles pour le traitement de troubles du système nerveux central (dont l'anxiété, la dépression, la schizophrénie et la maladie de Parkinson), les troubles musculaires (dont la dystrophie musculaire et la sclérose en plaques), la maladie d'Alzheimer, les troubles hématopoïétiques, la maladies allergiques, les maladies auto-immunes, les déficits immunitaires et les cancers, entre autres, et les épreuves diagnostiques pour ces maladies.
Beeley Lee James
Mathias Stephen L.
Gowling Lafleur Henderson Llp
Smithkline Beecham P.l.c.
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