C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/21 (2006.01) A61K 38/21 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) C12N 1/19 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2074802
The invention relates to new variants of type I interferon having one of the following formulae: X1-R0 (I); or X1-X2-R0 (II); or X1-X2-X3-R0 (III) wherein X1, X2 and X3 are similar or different and represent each an amino acid and Ro is the amino acid sequence of an interferon of type I, a cassette enabling their expression in the yeast, the invention also relating to the method for producing such variants from yeasts transformed by said cassette, as well as to their applications.
2074802 9209691 PCTABS00130 L'invention est relative à de nouveaux variants d'interféron de type I, répondant à l'une des formules suivantes: X1-R0 (I) ou bien X1-X2-R0 (II) ou bien X1-X2-X3-R0 (III) dans laquelle X1, X2 et X3 sont identiques ou différents, et représentent chacun un acide aminé et R0 représente la séquence en acides aminés de la forme mature d'un interféron de type I, une cassette permettant leur expression dans la levure, à leur procédé de production à partir de levures transformées par ladite cassette, et à leurs applications.
Chaouat Gerard
Charlier Madia
Charpigny Gilles
Degryse Eric
Gaye Pierre
Goudreau Gage Dubuc
Institut National de La Recherche Agronomique (inra)
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