Interleukin-1.beta. converting enzyme like cysteine protease

Details Interleukin-1.beta. converting enzyme like cysteine protease Interleukin-1.beta. converting enzyme like cysteine protease

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2236914

A new member of a family of ICE-like cysteine proteases has been identified. The protease family is termed LICE (like ICE) and the family member described herein is LICE3. LICE3 polypeptides, nucleic acids encoding LICE3 and vectors and host cells for the expression LICE3 are disclosed. Also disclosed are methods for identifying LICE3 agonists and antagonists, and methods for treatment of disorders characterized by altered apoptosis.

On a identifié un nouvel élément d'une famille de cystéine protéases de type ICE. La famille de protéases est appelée LICE (Like ICE), l'élément de la famille décrit dans cette invention étant le LICE3. L'invention concerne également des polypeptides de LICE3, des acides nucléiques codant pour LICE3, des vecteurs, des cellules hôtes pour l'expression de LICE3. Enfin elle porte sur des procédés d'identification d'agonistes et d'antagonistes de LIC3 et des procédés de traitement de troubles caractérisés par une apoptose modifiée.

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