Interleukin-1 inhibitors

Details Interleukin-1 inhibitors Interleukin-1 inhibitors

C - Chemistry, Metallurgy

12

N

230/13, 167/103.

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341322

IL-1 inhibitors are provided. According to certain embodiments, the IL-1 inhibitors comprise an amino acid sequence selected from: (i) all or an IL-1 inhibitory fragment of the following amino acid sequence: (U) (X) P S G R X S S K M Q A F R I W D V N Q K T F Y L R N N Q L V A G Y L Q G P N V N L E E R I D V V P I E P H A L F L G I H D d K M C L S C V R S G D E T R L Q L E A V N I T D L S E N R K Q D K R F A F I R S D S G P T T S F E S A A C P G W F L C T A M E A D Q P V S L T N M B D E G V M V T R F Y F Q E D E wherein (U) is nothing, M, or comprises an N- terminal leader sequence and (X) is R or P; or (ii) an amino acid sequence that is at least 70 % homologous to the amino acid sequence in (i).

600825

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