Interleukin-1 receptor-associated protein kinase and assays

Details Interleukin-1 receptor-associated protein kinase and assays Interleukin-1 receptor-associated protein kinase and assays

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 14/715 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2225450

The invention relates to human Interleukin-1 Receptor-Associated Protein Kinases (IRAKs), nucleic acids which encode IRAKs and hybridization probes and primers capable of hybridizing with IRAK genes and methods of using the subject compositions; in particular, methods such as IRAK-based in vitro binding assays and phosphorylation assays for screening chemical libraries for lead compounds for pharmacological agents.

Cette invention concerne des protéines kinases humaines associées au récepteur de l'Interleukine-1 (IRAK), les acides nucléiques qui codent les IRAK et les sondes et les armorces d'hybridation moléculaire capables de s'hybrider avec les gènes IRAK et les procédés d'utilisation des compositions en question; en particulier des procédés tels que des dosages de liaison in vitro à base d'IRAK et des dosages de phosphorylation destinés au criblage de banques chimiques pour détecter des composés principaux pour des agents pharmaceutiques.

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