Interleukin-1 receptors

Details Interleukin-1 receptors Interleukin-1 receptors

C - Chemistry, Metallurgy

12

N

167/37, 195/1.11

C12N 15/25 (2006.01) A61K 38/20 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) G01N 33/566 (2006.01)

Patent

CA 1341611

Mammalian Interleukin-1 receptor proteins (IL-1Rs), DNAs and expression vectors encoding mammalian IL-1Rs, and processes for producing mammalian IL-1Rs as products of cell culture, including recombinant systems, are disclosed. Purified IL-1 receptor compositions will be useful in diagnostic assays for IL-1 or IL-1 receptors and also for raising antibodies to the IL-1 receptor for diagnosis and therapy. Purified IL-1 receptor compositions may be used directly in therapy to bind or scavenge IL-1, thereby providing a means for regulating the immune or inflammatory activities of this cytokine.

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