Interleukin-12 as a veterinary vaccine adjuvant

Details Interleukin-12 as a veterinary vaccine adjuvant Interleukin-12 as a veterinary vaccine adjuvant

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2457563

This disclosure describes a composition for enhancing the immunogenicity of a veterinary vaccine that comprises a pharmacologically effective amount of an immunomodulator and an immunoadjuvant. Additionally, the disclosure describes a vaccine composition comprising an effective immunizing amount of an antigen, an immunomodulator, an immunoadjuvant and a pharmaceutically acceptable carrier. The compositions may optionally contain conventional, secondary adjuvants or preservatives. The disclosure further describes a unique method for enhancing or accelerating the immunogenicity of weak, immunosuppressive or marginally safe antigens by administering to an avian or mammalian species a pharmacologically effective amount of the aforesaid immunogenicity enhancing composition or an effective immunizing amount of the aforesaid vaccine composition.

L'invention concerne une composition destinée à augmenter l'immunogénicité d'un vaccin vétérinaire, cette composition comprenant une dose pharmacologiquement active d'un immunomodulateur et d'un immunoadjuvant. L'invention concerne également une composition de vaccin comprenant une dose immunisante active d'un antigène, d'un immunomodulateur, d'un immunoadjuvant et d'un support pharmaceutiquement acceptable. Ces compositions peuvent éventuellement contenir des conservateurs ou des adjuvants secondaires classiques. L'invention concerne en outre un procédé unique permettant d'augmenter ou d'accélérer l'immunogénicité d'antigènes faibles, immunosuppresseurs ou à innocuité limitée, ce procédé consistant à administrer à une espèce aviaire ou mammifère une dose pharmacologiquement active de la composition susmentionnée augmentant l'immunogénicité ou une dose immunisante active de la composition de vaccin susmentionnée.

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