Interleukin-12p40 variants with improved stability

Details Interleukin-12p40 variants with improved stability Interleukin-12p40 variants with improved stability

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) C12N 5/00 (2006.01) C12N 15/24 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2635618

Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

La présente invention concerne des polypeptides p40 de l'interleukine 12 (IL-12) modifiés. Les polypeptides modifiés présentent des altérations de la sous-unité IL-12p40 afin d'éliminer le site de la protéase entre les positions Lys260 et Arg261. Les polypeptides IL-12p40 modifiés selon l'invention ont une stabilité améliorée comparée aux polypeptides IL-12p40 humains matures de type sauvage.

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