Interleukin-13 binding proteins

Details Interleukin-13 binding proteins Interleukin-13 binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2662701

The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.

La présente invention concerne des protéines de liaison IL-13. Plus précisément, l'invention concerne des anticorps qui sont des anticorps chimériques, greffés CDR et humanisés. Les anticorps préférés ont une haute affinité pour l'hIL-13 et neutralisent l'activité d'hIL-13 in vitro et in vivo. Un anticorps de l'invention peut être un anticorps pleine longueur ou une partie de liaison à un antigène de celui-ci. Un procédé de préparation et un procédé d'utilisation des anticorps de l'invention sont également proposés. Les anticorps ou parties d'anticorps de l'invention s'utilisent pour détecter l'hIL-13 et pour inhiber une activité d'hIL-13, par exemple chez un être humain souffrant d'un trouble dans lequel l'activité d'hIL-13 est néfaste.

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