Interleukin-15

Details Interleukin-15 Interleukin-15

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/54 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2186747

There is disclosed a mammalian epithelium-derived T-cell factor ("ETF") polypeptide referred to herein as Interleukin-15 ("IL-15"), derivatives thereof, DNA sequences, recombinant DNA molecules and transformed host cells that produce IL-15 polypeptides. More particularly, this invention provides isolated mammalian IL-15 polypeptides and derivatives thereof that regulate events in T-lymphocyte proliferation.

On décrit un facteur polypeptidique agissant sur les cellules T, dérivé de l'épithélium de mammifères et appelé ici interleukine-15 (IL-15), ses dérivés, des séquences d'ADN, des molécules d'ADN de recombinaison et des cellules hôtes transformées qui produisent les polypeptides IL-15. Plus particulièrement, cette invention concerne des polypeptides IL-15 isolés de mammifères et leurs dérivés qui contrôlent certains aspects de la prolifération des lymphocytes T.

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