Interleukin-18 binding proteins, their preparation and use

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 7/01 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2298855

Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.

L'invention concerne des protéines de fixation de l'interleukine-18 capables de fixer l'IL-18 et/ou de moduler et/ou de bloquer l'activité IL-18. L'invention concerne également des procédés permettant leur isolement et leur production par recombinaison, des ADN les codant, des vecteurs d'ADN les exprimant, des vecteurs utiles à leur expression chez des sujets humains et autres sujets mammifères, ainsi que des anticorps contre elles.

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