Interleukin-2-leukotoxin gene fusions and uses therefor

Details Interleukin-2-leukotoxin gene fusions and uses therefor Interleukin-2-leukotoxin gene fusions and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/102 (2006.01) A61K 39/385 (2006.01) C07K 14/285 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C07K 19/00 (2006.01) C12N 15/26 (2006.01) C12N 15/31 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2089753

New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against re- spiratory diseases such as pneumonia; including shipping fever pneumonia, are disclosed. The chimeric proteins in- clude at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vacci- nation as well as methods of making the proteins employed in the vaccines.

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