Interleukin-2 mutants with reduced toxicity

Details Interleukin-2 mutants with reduced toxicity Interleukin-2 mutants with reduced toxicity

C - Chemistry, Metallurgy

07

K

C07K 14/55 (2006.01) A61K 38/20 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2456470

Interleukin-2 (IL-2) mutants having reduced toxicity, which include full- length IL-2, truncated forms of IL-2 and forms IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildtype form of the mutant IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.

L'invention concerne des mutants d'interleukine-2 (IL-2) présentant une toxicité réduite et comprenant une IL-2 longue, des formes tronquées d'IL-2 et des formes d'IL-2 liées à une autre molécule. Des substitutions particulières dans l'IL-2, notamment dans la région peptidique augmentant la perméabilité de l'IL-2, permettent d'obtenir une réduction substantielle de l'activité de vasoperméabilité par comparaison avec une forme de type sauvage de l'IL-2 mutante. Les mutants d'IL-2 de l'invention peuvent être utilisés pour stimuler le système immunitaire d'un animal, notamment dans le traitement de divers troubles et états pathologiques.

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