Interleukin-20

Details Interleukin-20 Interleukin-20

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 5/00 (2006.01) C12N 15/03 (2006.01) C12N 15/11 (2006.01) C12N 15/19 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2296762

The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

L'invention concerne une nouvelle protéine IL-20 appartenant à la famille des polypeptides de cytokine. En particulier, l'invention concerne des molécules d'acides nucléiques isolés codant la protéine humaine IL-20. L'invention concerne aussi des polypeptides d'IL-20, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant d'élaborer ces polypeptides. L'invention concerne en outre des procédés de criblage pour identifier les agonistes et les antagonistes vis-à-vis de l'activité de l'IL-20, ainsi que des procédés diagnostiques pour détecter les troubles liés au système immunitaire et des procédés thérapeutiques pour traiter les troubles en question.

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