Interleukin 21 and tyrosine kinase inhibitor combination...

Details Interleukin 21 and tyrosine kinase inhibitor combination... Interleukin 21 and tyrosine kinase inhibitor combination...

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/404 (2006.01) A61K 31/4412 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2656836

The present invention provides methods for use of IL-21 in combination with a tyrosine kinase inhibitor (TKI) in treatment of diseases in which inhibition of phosphorylation via TK inhibition and modulation of immune function play a clinically beneficial role. These diseases include, but are not limited to, cancers, such as renal cell carcinoma and metastatic melanoma.

La présente invention concerne des procédés pour l'utilisation d'IL-21 en combinaison avec un inhibiteur de tyrosine kinase (TKI) dans le traitement de maladies dans lesquelles l'inhibition de la phosphorylation par inhibition de TK et modulation de la fonction immune jouent un rôle cliniquement bénéfique. Ces maladies comprennent, sans y être limitées, les cancers, comme le cancer des cellules rénales et le mélanome métastatique.

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